Neuraxial Anesthesia – In spite of dramatic Partial thromboplastin time (PTT/aPTT) elevation, studies show that patients deficient in Factor XII can have normal hemostasis and are able to undergo major surgeries without plasma replacement.

Bleeding risk – Patients with this condition have been reported to be able to undergo major surgery and neuraxial anesthesia WITHOUT a platelet infusion in spite of the elevated PTT. Where bleeding complications are a risk, make sure to draw a CBC and coags to ensure adequate platelet levels and bleeding times.

Treatment – Fresh Frozen Plasma. Generally speaking, this is not necessary. Unnecessary infusion may cause an infection, and in some literature, is specifically recommended against.

Can be acquired or inherited (autosomal recessive).

Incidence is about 2.3% of the general population.

Patients affected with a deficiency in FXII typically do not experience abnormal bleeding because there is activation by other contact factors. Partial thromboplastin time (PTT/aPTT) is elevated.