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Afibrinogenemia and Hypofibrinogenemia

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Blood Loss (Excessive)AnemiaHypovolemiaHypotensionShockAvoid NeuraxialThrombosis Risk

Pathophysiology

Fibrinogen is a 340 kDa hexameric glycoprotein made in the liver from three genes on chromosome 4. It circulates at 200-400 mg/dL — the highest concentration of any coagulation factor — with a plasma...

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