Angelman Syndrome (AS)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated July 28, 2026

Difficult AirwayBradycardiaAvoid BradycardiaSeizuresParalytic SensitivityCopious SecretionsCareful PositioningDelayed EmergenceAvoid HyperglycemiaSkeletal Muscle WeaknessScoliosis

Pathophysiology

Angelman syndrome ( AS ) is a neurogenetic disorder caused by loss of function of the maternally inherited UBE3A gene at chromosome 15q11-13, most often from a de novo maternal deletion. Because the...

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Angelman Syndrome (AS)

Pathophysiology

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