Therapeutic Effects: Vasoconstriction and uterine contraction

Anesthesia Implications

Big concern about this drug is it can cause bronchoconstriction and hypertension. If this drug is used – its because the surgeon has requested it. Used to treat uterine atony (“boggy uterus”) after delivery of the placenta. The primary use is to slow postpartum bleeding/hemorrhage. Hemabate is typically used if Oxytocin was unsuccessful at slowing blood loss. Side effects also include tachypnea, vomiting, diarrhea, or increase in body temperature.

Contraindications

Hx of preeclampsia, asthma, hypo/hypertension, anemia, diabetes, epilepsy

IV infusion dose

NEVER. If requested, give slowly (>1min) and watch for hypertension and tachycardia.

IM dose: 250 mcg every 15 minutes. Max: 2mg (8 doses). This may also be injected directly into the uterus.

Classification: Prostaglandin with oxytoic properties, Uterotonic