Celecoxib (celeBREX)

Anesthesia Implications

Updated On: July 10, 2026

Classification:

Cox-2 Inhibitor (NSAID)

Time to Onset:

24 hours

Time to Peak Effects:

Unknown

Duration:

12-24hours

Primary Considerations:

Use PO in pre-op for acute pain following surgery in patients who need a multimodal pain plan. Good for cases that are longer as the peak onset is 24 hours after administration. A one time 400mg administration of celecoxib was shown to decrease need for larger dosages of oral analgesic medication post-operatively.

Contraindications:

IV push dose:

IV infusion dose:

IM dose:

Epidural bolus dose:

Epidural maintenance rate:

Spinal bolus dose:

Spinal maintenance rate:

Regional Bolus Dose:

PCA:

Method of Action:

Cox-2 enzyme inhibitor: anti-inflammatory, analgesic, and antipyretic properties

Metabolism:

Hepatic - CYP2C9

Elimination:

Renal

Reversal:

Additional Notes:

Avoid in people with hepatic disease, NSAID sensitivity, or pregnant individuals. Caution in cardiac patients as there is an increased risk for thrombotic events.

Master Anesthesia

Master Anesthesia

Celecoxib (celeBREX)

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