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Factor II Deficiency (Hypoprothrombinemia)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Blood Loss (Excessive)Careful PositioningAvoid NeuraxialFactor Replacement Required

Pathophysiology

Factor II is prothrombin — the vitamin K-dependent zymogen the liver makes and that factor Xa, using factor Va as its cofactor, cleaves into thrombin. Thrombin is where the cascade cashes out: it...

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