heart-rate-pulse-graph

Factor XI Deficiency (Hemophilia C, Rosenthal Syndrome, FXI)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Blood Loss (Excessive)AnemiaHypervolemiaAvoid NeuraxialFactor Replacement RequiredMassive Transfusion

Pathophysiology

Factor XI is an intrinsic-pathway serine protease made in the liver. XIIa activates XI, XIa activates IX, and IXa with factor VIII as cofactor activates X into the common pathway. Thrombin also feeds...

Continue reading

Read the full condition post with a free account

Free. It opens every drug, surgery and condition in the library.

Already have an account?