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Factor XIII Deficiency (Fibrin-Stabilizing Factor Deficiency, FXIII)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Blood Loss (Excessive)AnemiaCareful PositioningAvoid Neuraxial

Pathophysiology

Factor XIII is the fibrin-stabilizing factor and the last step of the cascade. Thrombin plus calcium strips its activation peptide and turns it into a transglutaminase that cross-links fibrin gamma...

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