Freeman-Sheldon Syndrome (Whistling Face Syndrome, FSS)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated July 22, 2026

Difficult AirwayVideo LaryngoscopeMalignant Hyperthermia RiskAvoid SuccinylcholineParalytic SensitivitySkeletal Muscle WeaknessAspirationC-spineCareful PositioningDifficult IV AccessLimited Mouth OpeningPostoperative Pulmonary Complications

Pathophysiology

Freeman-Sheldon syndrome is a congenital myopathy of facial, limb, and respiratory muscle with a reported prevalence under 1 per million. It is linked to mutations in MYH3 and other genes encoding...

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Freeman-Sheldon Syndrome (Whistling Face Syndrome, FSS)

Pathophysiology

Read the full condition post with a free account