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Glanzmann Thrombasthenia (GT)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Blood Loss (Excessive)AnemiaPONVAvoid Nasal InstrumentationAvoid NeuraxialMassive TransfusionPlatelet Dysfunction

Pathophysiology

Glanzmann thrombasthenia ( GT ) is an autosomal recessive defect of the platelet integrin alpha-IIb-beta-3 — the old GPIIb/ IIIa — from mutations in ITGA2B or ITGB3 on chromosome 17. That integrin is...

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