This course gives nurse anesthesiologists a practical, case-based approach to perioperative blood management—from choosing the right blood component (RBCs, platelets, FFP, cryoprecipitate) to knowing when not to transfuse. You’ll review indications, massive transfusion strategies, and point-of-care coagulation tools (TEG/ROTEM), alongside targeted pharmacologic options such as TXA, DDAVP, PCC, and recombinant factors. Emphasis is placed on recognizing and managing transfusion complications (TRALI, TACO, hemolytic reactions, citrate toxicity) while integrating blood conservation techniques and newer advances like pathogen-reduced products and synthetic oxygen carriers, so you can safely optimize hemostasis and outcomes in the OR.