This module dives into the clinical realities of managing perioperative pain in patients with Opioid Use Disorder—where tolerance, hyperalgesia, and relapse risk make “standard” opioid strategies unsafe and ineffective. You’ll learn how to screen for OUD, interpret and manage patients on MOUD (buprenorphine, methadone, naltrexone), and build practical multimodal plans that leverage regional anesthesia, ketamine, lidocaine, alpha-2 agonists, and thoughtful opioid rotation. From preoperative optimization through postoperative withdrawal assessment and support, this content gives you a step-by-step framework to provide real analgesia while minimizing opioid exposure and protecting a highly vulnerable population.