Amniotic fluid embolism is rare, sudden, and often lethal—leaving anesthesia providers with only seconds to act and limited definitive therapies. This course walks you through the pathophysiology of AFE and explores the emerging role of intralipid therapy, including mechanisms of action, dosing strategies, and comparison with ECMO, nitric oxide, and rFVIIa. Build a practical, evidence-informed approach so you can recognize AFE early and confidently consider intralipid as part of a coordinated, life-saving response.