Local Anesthetic Systemic Toxicity is rare—but when it happens, it’s fast, unforgiving, and easy to miss if you’re not looking for it. This course breaks down how local anesthetics trigger CNS and cardiovascular toxicity at the sodium channel level, then walks through the earliest subtle warning signs all the way to seizures, ventricular arrhythmias, and collapse. You’ll also review patient-, drug-, and procedure-related risk factors so you can spot high-risk scenarios in advance, recognize LAST in time to intervene, and tighten your overall safety profile in regional and neuraxial anesthesia practice.