This course gives Anesthesiologists a practical, systems-based look at neuraxial drugs—spinal, epidural, and caudal—linking where you inject to how it affects cardiovascular, pulmonary, and gastrointestinal physiology. You’ll compare the pharmacology of key local anesthetics (bupivacaine, lidocaine, ropivacaine, tetracaine) and adjuvants, understand how sodium channel blockade translates into real-world block characteristics, and learn to tailor drug choice and dosing to maximize efficacy and safety in diverse patient populations.