Providing anesthesia for patients with Opioid Use Disorder demands a highly individualized, multimodal strategy that balances effective pain control with the imperative to minimize opioid exposure. This course breaks down the challenges of opioid tolerance, dependence, hyperalgesia, and withdrawal, guiding you through evidence-based preoperative screening, MOUD management, regional anesthesia options, and intraoperative adjuncts like ketamine, lidocaine, alpha-2 agonists, and magnesium. You’ll also learn postoperative strategies—including opioid rotation and structured withdrawal assessment—to optimize outcomes while reducing risks. Equip yourself with the tools to deliver safe, compassionate, and effective care for this complex and vulnerable patient population.