This module equips anesthesia providers to safely care for patients with substance use disorders while also recognizing risks within their own practice environment. You’ll review the prevalence and impact of alcohol, opioids, stimulants, sedatives, and polysubstance use in the surgical population; explore how tolerance, withdrawal, and organ dysfunction alter anesthetic plans; and learn practical, evidence-based strategies including multimodal analgesia, regional techniques, and the use of adjuvants such as gabapentinoids, ketamine, and benzodiazepines. With a focus on real-world perioperative decision-making and interdisciplinary collaboration, this course helps you anticipate complications, individualize care, and support safer outcomes for a highly vulnerable patient population.