heart-rate-pulse-graph

Noonan Syndrome

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Difficult AirwayVideo LaryngoscopeAvoid HypovolemiaAvoid HypotensionAvoid TachycardiaAvoid Beta AgonistsAvoid HypoxiaAvoid HypercarbiaAvoid AcidosisAvoid Pulmonary HypertensionReduced Cardiac OutputArrhythmiasBlood Loss (Excessive)EdemaAspirationSudden Cardiac Death Risk

Pathophysiology

Noonan syndrome is an autosomal dominant RASopathy — a germline gain-of-function mutation in the RAS/MAPK signaling pathway, most often PTPN11, less often SOS1, RAF1 or RIT1. Prolonged RAS/MAPK...

Continue reading

Read the full condition post with a free account

Free. It opens every drug, surgery and condition in the library.

Already have an account?