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Paroxysmal Nocturnal Hemoglobinuria (PNH)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

AnemiaPulmonary HypertensionRenal DysfunctionStroke RiskImmunocompromiseOptimize HydrationAvoid StressorsAspirationHemolysis RiskThrombocytopeniaThrombosis Risk

Pathophysiology

Paroxysmal nocturnal hemoglobinuria (PNH) begins with an acquired somatic PIGA mutation in a hematopoietic stem cell clone. PIGA builds the glycosylphosphatidylinositol (GPI) anchor, so the clone's...

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