tablet-yellow

Piperacillin/Tazobactam (Zosyn)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Classification:
Extended-spectrum penicillin plus beta-lactamase inhibitor, beta-lactam antibiotic
Therapeutic Effects:
Bactericidal, broad-spectrum including Pseudomonas and anaerobes, surgical prophylaxis for high-risk cases
Primary Considerations:

Prophylaxis timing - Give within 60 minutes before incision; redose about every 2 hours intraoperatively. Reserved for high-risk or contaminated cases (e.g., hepatobiliary, complex colorectal)....

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