tablet-yellow

Protamine Sulfate (Prosulf)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Classification:
Heparin Antagonist
Therapeutic Effects:
Lowers ACT values, antagonizes heparin affects
Primary Considerations:

Can cause severe hypotension. This is caused, at least in part, by histamine release by degranulation of isolated Mast Cells. Diphenhydramine (Benadryl) can be given to prevent or attenuate the...

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