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Protein C Deficiency

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated

Stroke RiskBlood Loss (Excessive)Careful PositioningOptimize HydrationAnticoagulatedThrombosis Risk

Pathophysiology

Protein C is a vitamin K-dependent plasma serine protease. Thrombin, bound to thrombomodulin on the vascular endothelium, converts it to activated protein C (APC), which cleaves and inactivates...

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