Stiff Person Syndrome (SPS)

Anesthesia Implications

Clinically reviewed by anesthesia providers · Updated July 23, 2026

WithdrawalRefractory PainAvoid StressorsAvoid HypothermiaCareful PositioningParalytic SensitivitySkeletal Muscle WeaknessDelayed EmergenceSeizuresDysglycemiaBone FragilityPostoperative Ventilation Likely

Pathophysiology

Stiff person syndrome (SPS) is a rare autoimmune disorder of central inhibition - roughly 1 to 2 cases per million, twice as common in women, usually presenting between ages 20 and 60. Antibodies...

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Master Anesthesia

Master Anesthesia

Stiff Person Syndrome (SPS)

Pathophysiology

Read the full condition post with a free account